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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Luis Escobar | 270 | 2010-2024 | |
| 2 | Spike Wagner | 237 | 2033-2048 | |
| 3 | Lance Carter | 218 | 2037-2049 | |
| 4 | Callum Maybury | 215 | 2035-2044 | |
| 5 | Lee Dalby | 214 | 2018-2030 | |
| 6 | Augusto Villarreal | 213 | 2039-2047 | |
| 7 | Berhane Omondi | 208 | 2038-2050 | |
| 7 | Finley Stabb | 208 | 2013-2026 | |
| 9 | Jesús Vázquez | 207 | 2038-2045 | |
| 10 | Martin Villa | 196 | 2041-2051 | |
| 11 | Alfredo Elizarraraz | 187 | 2017-2029 | |
| 11 | José García | 187 | 2044-2056 | |
| 11 | Manuel Ortega | 187 | 2021-2027 | |
| 14 | Domingo Anaya | 185 | 2023-2030 | |
| 15 | Jerry Crawford | 183 | 2033-2044 | |
| 15 | Derrek Terry | 183 | 2034-2047 | |
| 17 | Tony Canales | 181 | 2023-2040 | |
| 17 | Alfonso Colomo | 181 | 2034-2044 | |
| 19 | Marcos Morales | 180 | 2038-2044 | |
| 20 | Luis López | 176 | 2013-2027 | |
| 21 | Santiago Pérez | 174 | 2034-2044 | |
| 21 | Bob Ramírez | 174 | 2037-2049 | |
| 23 | Justino Curva | 173 | 2040-2047 | |
| 24 | Issam Serres | 172 | 2039-2049 | |
| 24 | Mitchell Swanson | 172 | 2037-2045 | |
| 26 | Thomas Alexander | 169 | 2046-2059 | |
| 26 | Ignacio Gonzáles | 169 | 2026-2031 | |
| 28 | Roger Boyd | 168 | 1995-2006 | |
| 29 | Sven Kahn | 165 | 2037-2050 | |
| 29 | Vernon Lewis | 165 | 2016-2028 | |
| 29 | Darryl Otterson | 165 | 1997-2005 | |
| 32 | Mike Griffin# | 164 | 2049-2062 | |
| 33 | Lee Broadberry | 163 | 2047-2058 | |
| 33 | Hubert Rogers | 163 | 2015-2025 | |
| 35 | Roger Brown | 162 | 2019-2031 | |
| 35 | Jon Heard | 162 | 2019-2028 | |
| 35 | Ben Pyrmont | 162 | 2036-2047 | |
| 38 | Héctor Acevedo | 159 | 2020-2034 | |
| 38 | Rudy Forrest | 159 | 2034-2045 | |
| 38 | Bill Keefe# | 159 | 2050-2062 | |
| 41 | Wilson Fernández | 158 | 2031-2038 | |
| 41 | Berto Gámez | 158 | 2035-2042 | |
| 41 | Giomar Meregalli | 158 | 2047-2060 | |
| 41 | Luis Valenzuela | 158 | 2022-2036 | |
| 45 | Norberto Asconcio | 157 | 2040-2046 | |
| 46 | Felipe Méndez | 153 | 2042-2051 | |
| 46 | Héctor Méndez | 153 | 2016-2031 | |
| 48 | Dave Cline | 152 | 2050-2061 | |
| 48 | Douglas Simmons | 152 | 2051-2062 | |
| 48 | Jaques Sucena | 152 | 2019-2029 | |
| 51 | Luis Gonzáles | 151 | 2032-2041 | |
| 51 | Mick Woodall | 151 | 2033-2040 | |
| 53 | Ingo Bennaars | 150 | 2031-2043 | |
| 53 | Román Sánchez | 150 | 2037-2046 | |
| 55 | Cliff Sweeny | 149 | 2004-2012 | |
| 56 | Tony Cabrera | 148 | 2039-2049 | |
| 56 | Ernesto Lópes | 148 | 2037-2049 | |
| 56 | Christopher Robinson | 148 | 2017-2027 | |
| 59 | Bernardino Bertoletti | 147 | 2031-2039 | |
| 59 | Roberto Martínez | 147 | 2022-2035 | |
| 61 | António González | 146 | 2037-2042 | |
| 61 | Thomas Rodríguez | 146 | 2037-2053 | |
| 63 | Josh Herman | 145 | 2020-2027 | |
| 63 | Tommy Hunter | 145 | 2041-2047 | |
| 63 | Miguel Luna | 145 | 2034-2043 | |
| 63 | Luis López | 145 | 2040-2044 | |
| 63 | Jeremy Pompey | 145 | 2000-2010 | |
| 68 | Manny López | 144 | 2030-2039 | |
| 68 | Felipe Rosado | 144 | 2034-2043 | |
| 70 | Adrián Salazar | 143 | 2020-2026 | |
| 71 | Tony Rivera | 142 | 2035-2042 | |
| 72 | Rafael Rodríguez | 141 | 2042-2059 | |
| 72 | Jim Wilson | 141 | 2035-2040 | |
| 74 | Dae-hyun Kim | 140 | 2045-2055 | |
| 74 | Alberto Magana | 140 | 2026-2030 | |
| 74 | José Méndez | 140 | 2022-2030 | |
| 74 | Bryan Tite# | 140 | 2052-2062 | |
| 78 | Brendon Carr | 139 | 2034-2048 | |
| 78 | Iván Ruíz# | 139 | 2044-2062 | |
| 78 | António Árias | 139 | 2035-2043 | |
| 81 | James House | 138 | 2048-2058 | |
| 81 | Augusto Vásquez | 138 | 2041-2050 | |
| 83 | Robbie Cooke | 137 | 2031-2045 | |
| 83 | León González | 137 | 2026-2037 | |
| 83 | Gunner Patterson# | 137 | 2055-2062 | |
| 86 | Adel bin Ibrahim | 136 | 2033-2046 | |
| 86 | Jesús Galván | 136 | 2019-2027 | |
| 86 | Steve Hernández | 136 | 2041-2050 | |
| 86 | Chang-ho Kim | 136 | 2038-2045 | |
| 90 | Gurmu Icharia | 135 | 2033-2048 | |
| 90 | Ghi-cheng Kum | 135 | 2035-2053 | |
| 90 | Albie Lopez | 135 | 1997-2008 | |
| 90 | Brad Peckford# | 135 | 2049-2061 | |
| 94 | Juan Pagán | 134 | 2027-2037 | |
| 94 | Randall Thomas | 134 | 2023-2039 | |
| 96 | Stacy Bashir | 133 | 1995-2006 | |
| 96 | Ron Frazier | 133 | 2043-2047 | |
| 96 | José Seánez | 133 | 2026-2031 | |
| 99 | John Brown | 132 | 2046-2052 | |
| 100 | Danny Hudson | 131 | 2023-2031 |
